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KMID : 1040320180250020107
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Pediatric Infection & Vaccine
2018 Volume.25 No. 2 p.107 ~ p.112
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Recurrent Familial Furunculosis Associated with Panton-Valentine Leukocidin-Positive Methicillin-Susceptible Staphylococcus aureus ST1
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Lee Jin-Young
Park Ji-Young
Bae Il-Kwon
Jeong Se-Ri
Park Ji-Hyun
Jin Sol
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Abstract
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Staphylococcus aureus is now a major community-acquired pathogen worldwide, notably associated with skin and soft tissue infections. Staphylococci are present in the form of colonizers or environmental contaminants at home and increase the risk of recurrent infection. We are describing recurrent familial furunculosis caused by Panton-Valentine Leukocidin-positive methicillin susceptible S. aureus ST1 in Korea. An infant, his father and mother had furunculosis due to methicillin-sensitive S. aureus (MSSA) infection with identical susceptibility patterns. ST1 accounted for all 3 isolates and they were confirmed of having agr group I. Both sec and seh were detected in all isolates using polymerase chain reaction (PCR) assays, and all isolates contained Panton-Valentine leukocidin (PVL) genes. Risk factors for the household spread of S. aureus include skin conditions and close physical contact among household members. The relationship between S. aureus colonization of household contacts and the occurrence of S. aureus infection should be studied into more detail.
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KEYWORD
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Staphylococcus aureus, Furunculosis, Family characteristics, Panton-Valentine leukocidin
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